Objective To study the effect of movement rehabilitation combined with drug intervention on vascular dementia ( VD) rats.Methods VD model rats were prepared by permanent bilateral common carotid artery ligation .50 SD rats were randomly divided into normal control,VD model,medication,exercise rehabilitation and exercise rehabilitation combined treatment groups .After movement combined with drug rehabilitation intervention for 8 w,the behavior of VD model rats was assessed and the rat hippocampal neurons were detected by light microscopy ,electron microscopy and calcium ion fluorescence .Results The latentperiod of platform test and the dark avoidance test were significantly prolonged for exercise rehabilitation combined treatment group .The times through the platform were increased significantly ( P<0.05).The result of light microscopy and electron microscopy showed that the hippocampus neuron damage was reduced significantly and the calcium fluorescence was decreased obviously .Conclusions The intervention effect of exercise rehabilitation combined drug is superior to the single drug treatment.%目的：研究运动康复联合药物干预对血管性痴呆（ VD）的治疗作用。方法采用双侧颈总动脉永久性结扎制备大鼠VD模型，将50只SD大鼠随机分为正常对照组、VD模型组、药物治疗组、运动康复组、运动康复联合药物组。 VD模型大鼠经过运动康复联合药物干预8 w后，对大鼠进行行为学评估，并对大鼠海马区神经元进行光镜、电镜检测以及钙离子荧光检测。结果运动康复联合药物组大鼠跳台实验和避暗实验潜伏期明显延长，通过平台次数明显增加（ P＜0．05）。光镜、电镜检测发现运动康复联合药物组大鼠海马区神经元损伤明显减轻，钙离子荧光明显减弱。结论运动康复联合药物治疗对VD的干预效果优于单独的药物治疗。
展开▼
