Objective To study effect of L-arginine and citrulline on endothelial function in patients with chronic congestive heart failure. Methods 30 subjects confirmed diagnosis of chronic congestive heart failure were recorded index finger pulse wave by photoplethys-mography. Then the data about basal and each 30 s intervals by maximum amplitude time, total time and the ratio of the two before and after the administration of L-arginine or citrulline for two months were measured. Results There were no statistically significant differences in the basal data between the two groups before the administration of L-arginine or citrulline. However, after the administration, the ratio of maximum amplitude time/total time was significantly lower than basal data. Conclusions There is an advantageous influence on endothelial function by taking L-arginine and citrulline orally. It may reduce blood pressure and improve pulmonary hemodynamics in favor of the treatment of chronic congestive heart failure.%目的 研究口服L-精氨酸和瓜氨酸对慢性充血性心力衰竭(CHF)患者内皮功能的影响.方法 用光电体积描记术记录30名确诊病人食指脉搏波.测定口服L-精氨酸和瓜氨酸试验前后静息状态下脉搏波和缺血后每30秒时间段的最大脉搏波时长、总时长以及两者之间的比值.结果 两组受试者试验前脉搏波无明显差异.口服氨基酸后,每30秒时间段的最大脉搏波时长/总时长比值较试验前均有显著差异.结论 口服L-精氨酸和瓜氨酸有助于改善内皮功能,减低血压和肺动脉收缩压,辅助治疗CHF.
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