目的：研究强直性脊椎炎（AS）和类风湿性关节炎（RA）患者外周血中Th1细胞、Th17细胞和Th22细胞的表达，为进一步探讨AS和RA的发病机制提供新的理论依据。方法采用流式细胞术测定38例AS患者、40例RA患者及30名健康体检者外周血中Th1细胞、Th17细胞及Th22细胞的含量。结果AS患者Th17和Th22细胞的含量分别为（3.78±1.93）%、（1.63±0.53）%，RA患者Th17和Th22的含量分别为（3.66±1.84）%、（1.58±0.65）%。结果显示，与健康对照相比， AS和RA患者的Th17和Th22细胞的含量差异都有统计学意义（P＜0.05）。结论AS和RA患者外周血中Th22细胞和Th17细胞含量上升，提示Th22细胞和Th17细胞与AS和RA的发病机制有关。%Objective To investigate the expression of Th1 cells, Th17 cells and Th22 cells in peripheral blood from patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA), and provide the reference for the further research of AS and RA pathological mechanism. Methods A total of 38 AS, 40 RA and 30 healthy subjects were enrolled in the research. The expression percentages of Th1, Th22 and Th17 cells were determined by flow cytometry. Results The expression of Th17 and Th22 cells in AS patients were (3.78±1.93)%, (1.63±0.53)%respectively, while in RA patients, they were (3.66±1.84)%and (1.58±0.65)%, respectively. The results showed that the expressions of Th17 and Th22 cells in AS patients were significantly higher than those of healthy controls (P<0.05), as well as RA patients. Conclusion The expression of Th17 and Th22 cells were increased in peripheral blood from patients with AS and patients with RA. These findings suggest that Th17 cells and Th22 cells may be implicated in the pathogenesis of AS and RA.
展开▼
