Kallmann综合征(Kallmann syndrome,KS)是一种罕见的伴有嗅觉缺失的先天性促性腺功能低下疾病,呈家族性或散发性发病,具有明显的遗传异质性.目前只有KAL1、FGFR1、PROKR2、PROK2、CHD7以及FGF8被鉴定为KS致病基因,但只能解释25％ ～ 30％的KS病例.对WDR11、NELF、HS6ST1、DUSP6、SPYR4、IL17RD、SEMA3A、HESX1等KS的候选基因研究较少.文章就以上kallmann候选基因的研究进展进行综述.%Kallmann syndrome (KS) is a rare congenital hypogonadism associated with olfactory loss.It is familial or sporadic and has significant genetic heterogeneity.Only KAL1,FGFR1,PROKR2,PROK2,CHD7 and FGF8 are identified as KS pathogenic genes at present,but only in 25％ to 30％ of KS cases.There are few candidate genes for KS in WDR11,NELF,HS6ST1,DUSP6,SPYR4,IL17RD,SEMA3A and HESX1.In this paper,the progress of Kallmann candidate genes is reviewed.
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