目的:探究胃肠道卵巢转移癌患者人附睾蛋白4(HF4)的水平及临床意义.方法:选择在我院治疗的16例胃肠道卵巢转移癌患者作为观察组.同时选取期间在我院治疗的48例卵巢原发性癌患者为原发组.化学发光免疫分析仪检测两组患者血清HE4、CA125和CEA的浓度水平.结果:原发组血清HE4和CA125水平均显著高于观察组,差异有统计学意义(P＜0.05);此外,观察组中HE4的阳性例数和比例均明显多于CA125(P＜0.05);采用HE4和CEA联合方式在诊断的阳性率方面多于其他两组.结论:HE4作为卵巢癌肿瘤标志物,更适合胃肠道卵巢转移癌患者的诊断检测.临床可采用HE4和CEA联合检测,对于提高胃肠道卵巢转移癌的诊断具有重要的临床价值.%Objectives:To analyze the clinic significance of human epididymis protein 4 (HE4) in patients with ovarian metastatic cancer of gastrointestinal origin.Methods:16 patients with ovarian metastatic cancer of gastrointestinal origin were selected as observation group and 48 primary ovarian cancer patients were as primary group.The levels of serum HE4,CA125 and carcino embryonic antigen (CEA) were measured by chemiluminescence immunity analyzer.Results:Levels of serum HE4 and CA125 were significantly higher in primary group than those in observation group,with significant difference (P ＜ 0.05).Besides,the number and proportion of HE4 positive cases in observation group were significantly higher than these of CA125 positive cases (P ＜ 0.05).In addition,combined detection of HF4 and CEA was more superior.Conclusion:As a marker of ovarian cancer,HE4 is more suitable for the diagnosis of ovarian metastatic cancer of gastrointestinal origin.It has important clinical value by using combined detection of HE4 and CEA which can improve the diagnosis of ovarian metastatic cancer with gastrointestinal origin.
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