Objectives:To explore the relationship of levels of seminal plasma lipoprotein (a),Zn2 +and prostate specific antigen in the semen with abnormal semen liquefaction.Methods:200 patients with abnormal se-men liquefaction and 200 men with semen liquefaction were selected.The level of seminal zinc was detected by color-developing method.The level of PSA in seminal was measured by ELISA and the lipoprotein (a)was measured by latex enhanced immunoturbidimetric assay.Results:The levels of Zn2 + in abnormal group and normal group were (90.0 ±35.1 )μg/mL and (1 25.1 ±25.5)μg/mL respectively,with significant difference (P <0.01 ).The levels of lipoprotein (a)in abnormal group and normal group were (550 ±250)μg/mL and (301 ±98)μg/mL re-spectively,with significant difference (P <0.01 ).The levels of PSA in abnormal group and normal group were (0.81 ±0.21 )mg/mL and (1 .31 ±0.30)mg/mL respectively,with significant difference (P <0.05).Conclu-sion:The levels of seminal lipoprotein (a),Zn2 + and PSA should be taken into account in the diagnosis of male in-fertility caused by abnormal liquefaction.%目的：探讨精浆脂蛋白（a）、锌和前列腺特异性抗原（PSA）与精液液化的关系。方法：筛选精液液化异常患者和精液液化正常男性各200例，显色法测定精浆锌离子（Zn2＋），酶联免疫法测定 PSA，乳胶增强免疫透射比浊法测定脂蛋白（a），对比分析两组测定结果。结果：异常组精浆 Zn2＋平均含量为（90．0±35．1）μg／mL，脂蛋白（a）水平为（550±250）μg／mL；正常组精浆 Zn2＋平均含量为（125．1±25．5）μg／mL，脂蛋白（a）水平为（301±98）μg／mL，两者差异有统计学意义（均 P ＜0．01）。异常组精浆 PSA 含量为（0．81±0．21）mg／mL，正常组精浆 PSA 含量为（1．31±0．30）mg／mL，两者差异有统计学意义（P ＜0．05）。结论：精液液化异常可能与精浆脂蛋白（a）水平增高，Zn2＋及 PSA 含量偏低有一定的相关性。
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