To discuss the influence and prevention reoccurrence function of recombinant hu-man interferonα-2b Gel combined with Valaciclovir on cellular immune function of patients with recrudescent geni-tal herpes (GH).Methods:84 patients with recrudescent GH were selected and divided into control group and ob-servation group at random.The patients in two groups were given 300mg Valaciclovir capsules twice a day through the mouth with empty stomach before dinner for 4 weeks.The patients in observation group were additionally given recombinant human interferonα-2b Gel,which was greased locally four times a day for 10 days.Except for recom-binant human interferon α-2b Gel,the patients in control group were given the same medical treatment as that in observation group.The changes of peripheral blood T lymphocyte subsets of patients in two groups before and after medical treatment were observed,and reoccurrence rates of 6 months’and 1 year’s following-up was compared. Results:After 4 weeks’medical treatment,the peripheral blood CD4 +levels and CD4 +/CD8 +ratio of patients in observation group obviously higher than before,while CD8 +level obviously declined (P<0.05 and P<0.01 ), and no obvious difference appeared in control group before and after medical treatment (P>0.05).According to 6 months’and 1 year’s following -up,the reoccurrence rates of patients in observation group were 26.19% and 47.62%,which were all much lower than those in control group (47.62 %and 73.81 %)(χ2 =4.14 and 6.04, P<0.05).Conclusion:The treatment of recombinant human interferon α-2b Gel combined with valaciclovir on recrudescent GH,can adjust the functional disorder of peripheral blood T lymphocyte subsets and strengthen the cel-lular immune function,which,therefore,reduces the reoccurrence rate and can prevent reoccurrence.%目的：探讨重组人干扰素α-2 b凝胶联合伐昔洛韦对复发性生殖器疱疹（GH ）患者细胞免疫功能的影响及预防复发作用。方法：选择复发性GH患者共84例，随机分为两组（对照组与观察组）。两组患者均予以伐昔洛韦胶囊300mg，2次/d，饭前空腹口服，连用4周。观察组患者加用重组人干扰素α-2b凝胶局部涂擦，4次/d，连用10d。对照组患者除不使用重组人干扰素α-2b凝胶外余治疗同观察组。观察两组患者治疗前和治疗4周后外周血T淋巴细胞亚群的变化，并比较治疗后随访6个月及1年内的复发率。结果：治疗4周后，观察组患者外周血CD4＋水平和CD4＋/CD8＋比值较前明显上升，CD8＋水平较前明显下降（P＜0.05或P＜0.01），而对照组治疗前后比较差异不明显（P＞0.05）。治疗后随访6个月及1年，观察组的复发率分别为26.19％和47.62％，均明显低于对照组的47.62％和73.81％（χ2＝4.14和6.04，P＜0.05）。结论：重组人干扰素α-2 b凝胶联合伐昔洛韦治疗复发性GH能调节外周血T淋巴细胞亚群功能紊乱，增强其细胞免疫功能，从而能降低其复发率，具有预防复发作用。
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