To investigate the disease cause of infertility patients in Luohe city,and provide the treatment basis for infertility patients.Methods:254 infertility patients in three hospitals in Luohe city from 2010 to 2014 were randomly selected as the research objects.There were 122 male patients and 132 female patients.The patients were selected according to infertility diagnosis standards.For selected patients,we provided systemic exam-ination and treatment,analyzed clinical data of patients with induction and statistics.Results:The multiple factors logistic analysis results showed that the major factors of male infertility were oligospermatism,sexual dysfunction, genital infection,congenital dysplasia.Factors of female infertility were mainly blocked ovulation,abnormal im-mune,endocrine disorders,congenital dysplasia,uterine anomaly,etc.Conclusion:Abnormal semen,congenital dysplasia,genital infection,female uterus abnormal,blocked ovulation and male sexual disorder are the main fac-tors causing infertility.Therefore,targeted treatment is needed to deal with different etiology of patients to reduce the incidence of infertility.%目的：探究漯河市不孕不育症患者发病病因，为不孕不育症患者的治疗提供有效凭据。方法：选取于2010至2014年在漯河市3所医院确诊为不孕不育症患者中随机选取254例作为研究对象。其中男性患者122例，女性患者132例。所选患者均符合不孕不育症诊断标准。对所选患者采取系统性检查及治疗，对患者临床资料进行分析归纳，并进行统计。结果：经多因素Logistic分析结果表明，导致男性不孕症因素主要是精少、精弱、性交障碍、生殖器感染、先天性发育异常等；女性不孕症因素主要是排卵受阻、免疫异常、内分泌失调、先天性发育异常、子宫异常等。结论：精液异常、先天性发育异常、生殖器感染、女性子宫异常、排卵受阻、男性性交障碍是导致不育不孕的主要因素，故应对不同病因的病患进行针对性治疗，降低不育不孕发生率。
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