Objective:To explore whether Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses.Methods:C57BL/6 mice were immunized with MOG35-55 peptides,and evaluated for clinical neurological score every day .10 mice of the EAE were injected with Tuftsin subcutaneously .The spinal cord were stained by the methods of Haematoxylin Eosinstain , Luxol Fast Blue stain.The mRNA expression of IL-10 and TNF-αfrom brian tissue were detected at the 28 days by RT-PC method.Results:The controlled mice had no symptoms of disease and HE ,LFB were normal.Comparison EAE group with Tuftsin group of HE,LFB,EAE group were server than Tuftsin group.The expression of IL-10 in Tuftsin group was higher than EAE group.The expression of TNF-αin Tuftsin group was lower than EAE group .Conclusion: Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses .%目的：探索促吞噬肽（ Tuftsin ）在实验性自身免疫性脑脊髓炎（ Experimental autoimmune encephalomyelitis ， EAE）小鼠模型中的神经功能改善作用。方法：用髓鞘少突胶质细胞糖蛋白35－55（ MOG35－55）免疫C57 BL／6小鼠，应用微量注射泵皮下缓慢注射500μmol／L Tuftsin。每天对各组小鼠进行神经功能评分，免疫后28 d处死各组小鼠并取其脑和脊髓组织，观察并比较各组炎性细胞浸润部位及程度、有无脱髓鞘及脱失程度，以及比较各组 IL－10和TNF－α的表达情况。结果：①Tuftsin干预组小鼠发病率比EAE模型组低，平均神经功能评分小于EAE模型组（ P＜0．05）。②Tuftsin干预组较EAE模型组炎性细胞的浸润程度和髓鞘的脱失程度及范围减轻（ P＜0．05）。③Tuftsin干预组的IL－10的表达量比EAE模型组高（ P＜0．05），TNF－α的表达比EAE模型组低。结论：Tuftsin通过降低炎性反应、增强抗炎作用在中枢神经系统中发挥保护功能，降低EAE模型小鼠的炎性细胞浸润及脱髓鞘程度，减缓EAE小鼠的症状、促进其神经功能的恢复。
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