Objective To evaluate whether there is a correlation among plasma levels of procalcitonin (PCT),N-terminal pro-brain natriuretic peptide (NT-pro-BNP)and cardiac troponin T (cTnT)in patients with sepsis,as well as significance to prognosis of patients.Methods 48 patients with sepsis who were admitted to the intensive care unit of a hospital between September 2014 and March 2015 were chosen for study,patients were divided into severe and mild sepsis groups according to the disease condition,plasma levels of PCT,NT-pro-BNP,and cTnT were de-tected,mortality of patients were analyzed statistically,relation between plasma levels of PCT,NT-pro-BNP,cT-nT and patients’death were compared.Results The plasma levels of PCT,NT-pro-BNP and cTnT in severe sepsis group were significantly higher than those in mild sepsis group (all P <0.05);mortality of mild sepsis group was significantly lower than that of severe sepsis group (10.53% vs 41.38%,P <0.05);Levels of PCT,NT-pro-BNP and cTnT levels in died patients were all higher than surviving patients (all P <0.05);levels of PCT and NT-pro-BNP,NT-pro-BNP and cTnT were positively correlated respectively (rs = 0.337,P <0.05;rs =0.456,P =0.001, respectively ),while PCT was not significantly correlated with cTnT.Plasma levels of PCT,NT-pro-BNP,and cTnT were all correlated with the prognosis of patients (P <0.05),and is helpful for judging the prognosis of pa-tients,combination of three indexes had better prognostic value for the prognosis.Conclusion Combination detec-tion of plasmid levels of PCT,NP-pro-BNP,and cTnT can assess the severity of infection in patients with sepsis, and preliminarily judge the prognosis of patients with sepsis.%目的：探讨脓毒症患者血浆降钙素原（PCT）、氨基末端脑钠肽前体（NT-pro-BNP）与肌钙蛋白 T（cT-nT）水平是否存在相关，以及对患者预后的意义。方法选取2014年9月—2015年3月某院重症监护病房（ICU）收治的48例脓毒症患者，按严重程度分成重度和轻度两组，检测患者血浆中 PCT、NT-pro-BNP 及 cTnT 水平，并统计患者的死亡结局情况，比较分析两组患者血浆 PCT、NT-pro-BNP、cTnT 水平与其死亡情况的关系。结果重度脓毒症组患者血浆中 PCT、NT-pro-BNP、cTnT 水平均高于轻度脓毒症组患者，差异具有统计学意义（均 P ＜0．05）；轻度脓毒症患者病死率为10．53％，低于重度脓毒症患者（41．38％），差异有统计学意义（P ＜0．05）；死亡组患者的 PCT、NT-pro-BNP 与 cTnT 水平均高于存活组（均 P ＜0．05）；相关分析发现脓毒症患者血浆中 PCT 与NT-pro-BNP 呈正相关（rs ＝0．337，P ＜0．05），NT-pro-BNP 与 cTnT 之间也呈正相关（rs ＝0．456，P ＝0．001），而PCT 与 cTnT 无显著相关。预后分析发现脓毒症患者血浆中 PCT、NT-pro-BNP、cTnT 水平均与患者预后相关（P＜0．05），并且对患者的预后均有较好的判别作用，与独立指标相比，当三个指标组合时对预后判别能力更好。结论联合检测脓毒症患者血浆 PCT、NP-pro-BNP 与 cTnT 水平可评估脓毒症患者感染的严重程度，并初步判断脓毒症患者的预后。
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