目的：了解重症监护室（ICU）导管相关血流感染（CRBSI）的危险因素，为其预防控制提供科学依据。方法选取2008年1月-2012年12月某院 ICU 行中心静脉置管（CVC）且时间＞48 h 的住院患者1677例，分为CRBSI 组和非 CRBSI 组，对其进行危险因素分析。结果 CVC 使用率为92．88％（21041 d）；发生 CRBSI 86例， CRBSI 发生率为5．13％，千导管日 CRBSI 发生率为4．02/1000，CRBSI 组患者病死率为58．14％（50/86），显著高于非CRBSI 组的36．83％（586/1591），差异有统计学意义（χ2＝15．74，P ＜0．01）。多因素 logistic 回归分析结果显示，入住ICU 时间＞5 d、CVC 时间＞5 d、CVC 次数＞1次是 CRBSI 的危险因素（均 P ＜0．01）。结论了解 ICU 住院患者CRBSI 状况及其危险因素，可为进一步开展目标性监测，实现 CRBSI“零宽容”的奋斗目标提供参考。%Objective To study the risk factors for catheter-related bloodstream infection (CRBSI)in an intensive care unit (ICU),and provide scientific evidence for CRBSI prevention and control.Methods 1 677 ICU patients with central venous catheterization (CVC)for>48 hours between January 2008 and December 2012 were divided in-to CRBSI group and non-CRBSI group,risk factors for CRBSI were analyzed.Results The utilization rate of CVC was 92.88% (21 041 d);86 (5.13%)patients developed CRBSI,the incidence of CRBSI per 1 000 catheterization-day was 4.02,the mortality of CRBSI group was significantly higher than non-CRBSI group (58.14% [50/86]vs 36.83%[586/1 591])(χ2 =15.74,P <0.01 ).Multivariate logistic regression analysis showed that the risk factors for CRBSI in-cluded length of stay in ICU>5 days,CVC>5 days,the episode of CVC>1 (P <0.01).Conclusion Realizing the occur-rence status and risk factors of CRBSI in ICU patients can provide reference for further targeted monitor and implementation of zero tolerance goal of the CRBSI.
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