目的：观察痔瘘洗剂联合加味四黄膏对肛窦炎患者的临床疗效及安全性。方法将100例肛窦炎患者随机分为观察组和对照组各50例。对照组给予口服头孢丙烯分散片及局部化痔栓塞肛治疗，观察组给予中药痔瘘洗剂局部熏蒸及坐浴患处同时联合加味四黄膏局部外敷治疗。7 d为1个疗程，2组均治疗2个疗程。观察患者治疗前后中医症候积分，评价2组临床疗效，观察2组患者各项症状缓解时间、住院时间、6个月内的复发率及不良反应。结果2组治疗后中医证候积分均较治疗前明显改善（P＜0.01），且观察组低于对照组（P＜0.01）。观察组总有效率为96.0%（48/50），对照组为80.0%（40/50），差异有统计学意义（P＜0.01）。观察组肛门水肿、肛门潮湿、肛门疼痛、肛门坠胀症状缓解时间均明显短于对照组（P＜0.01）。观察组患者平均住院时间为（15.25±2.78）d，对照组为（18.46±3.41）d，2组比较差异有统计学意义（P＜0.01）。观察组随访2、4、6个月复发率分别为0、0、2.0%，对照组分别为4.0%、12.0%、16.0%，对照组4、6个月复发率均明显高于观察组（P＜0.05）。2组均未出现明显不良反应。结论痔瘘洗剂联合加味四黄膏治疗肛窦炎临床疗效好，复发率低，安全性高。%Objective To observe the clinical efficacy and safety ofZhilou Lotion combined with modified Sihuang Ointment in treatment of anal cryptitis.MethodsOne hundred patients with anal cryptitis were randomly divided into observation group and control group, with 50 cases in each group. The control group was given propylene dispersible tablets oral and topicalHuazhi embolism. The observation group received steaming and hip bath with Zhilou Lotion combined with modifiedSihuang Ointment topical external application treatment, 7 days as a course of treatment and 2 courses successive. The TCM syndrome scores of two groups were compared before and after treatment to evaluate the clinical efficacy. The remission time of symptoms, hospitalization time, recurrence rate in 6 months and adverse reactions were observed.Results After treatment, the TCM syndrome scores of two groups were improved (P<0.01), and the scores in the observation group was lower than those in the control group (P<0.01). The total effective rate was 96.0% (48/50) in the observation group, and 80.0% (40/50) in the control group, with statistical significance (P<0.01). The remission time of anal edema, anal dampness, anal pain and anal fall-swell in observation group was obviously shorter than that in the control group, with statistical significance (P<0.01). The average hospitalization time was (15.25±2.78) days in the observation group and (18.46±3.41) days in the control group, the difference was significant (P<0.01). In the observation group, the recurrence rate was 0, 0 and 2.0% in 2, 4, 6 months follow-up, while that was 4.0%, 12.0% and 16.0% in the control group, respectively. The recurrence rates of the control group in 4 months and 6 months were higher than those of the observation group (P<0.05). No significant adverse reactions occurred in the two groups.Conclusion Zhilou Lotion combined with modifiedSihuang Ointment has good clinical efficacy in treatment of anal cryptitis, with low recurrence rate and high safety.
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