目的：观察针刺联合盐酸帕罗西汀片治疗轻中度抑郁症临床疗效及其不良反应。方法将73例轻中度抑郁症患者随机分为2组。观察组40例,予针刺及盐酸帕罗西汀片口服；对照组33例,仅予盐酸帕罗西汀片口服。疗程6周。观察2组临床疗效,治疗前及治疗1、2、4、6周汉密顿抑郁量表(HAMD),治疗前及治疗2、4、6周抗抑郁药副反应量表(SERS)评分。结果观察组临床总有效率为78.95%(30/38),对照组为68.75%(22/32),差异无统计学意义(P＞0.05)。观察组治疗2、4、6周HAMD评分明显降低(P＜0.05,P＜0.01),对照组治疗4、6周HAMD评分明显降低(P＜0.05),治疗4周时2组HAMD评分比较差异有统计学意义(P＜0.05)。2组治疗4、6周SERS评分比较差异有统计学意义(P＜0.05)。结论针刺联合盐酸帕罗西汀片抗抑郁效果显著且能减少不良反应。%Objective To observe the clinical efficacy and reverse reactions of acupuncture combined with paroxetine hydrochloride in the treatment of mild or moderate depression. Methods The patients with mild or moderate depression (n=73) were randomly divided into control group (treated with paroxetine hydrochloride,n=33) and observation group (treated with acupuncture and paroxetine hydrochloride,n=40). The therapeutic course lasted for 6 weeks. The total score changes of Hamilton Depression Scale (HAMD) were observed before treatment and treated for 1, 2, 4 and 6 weeks. Rating Scale for Side Effects (SERS) was evaluated before treatment and treated for 2, 4, 6 weeks.Results The total effective rate of clinical efficacy in the observation group was 78.95% (30/38) and the control group was 68.75% (22/32), without significant difference between the two groups (P>0.05). The scores of HAMD decreased 4, 6 weeks after the treatment in the control group and 2, 4, 6 week after the treatment in the observation group compared with those in the same group before the treatment (P<0.05,P<0.01). There was a significant difference in HAMD scores between two groups after the treatment for 4 weeks (P<0.05). The scores of SERS showed a significant difference 4, 6 weeks after the treatment between the two groups (P<0.05).Conclusion Acupuncture can improve the curative effect of paroxetine hydrochloride and decrease its side effects in the treatment of depression.
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