Two new structural similar oxovanadium(Ⅴ)complexes with the formulae[VOL(OCH3)(CH3OH)](L=L1=2-chloro-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide(1); L=L2=2-chloro-N′-(2-hydroxy-3-methoxybenzyli-dene)benzohydrazide(2)),have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction.The V atom in each complex is in an octahedral coordination,with the three donor atoms of L and one methanolato O atom defining the equatorial plane,and with one oxo O atom and one methanol O atom occupying the axial positions.The complexes were evaluated for their urease inhibitory activities.The percent inhibition of the complexes 1 and 2 at the concentration of 100 μmol·L-1 on Helicobacter pylori urease are 82.0％±2.8％ and 28.2％±1.7％.The molecular docking study of the complexes with the urease was performed.CCDC:844338,1; and 844339,2.%本文合成了2个新的结构类似的酰腙氧钒(V)配合物,[VOL(OCH3)(CH3OH)](L=L1=2-氯-N′-(5-氯-2-羟基苯亚甲基)苯甲酰肼(1)；L=L2=2-氯-N′-(2-羟基-3-甲氧基苯亚甲基)苯甲酰肼(2)),并通过物理化学方法和单晶X-射线衍射表征了它们的结构.在每个配合物中,V原子都采取八面体配位构型,利用配体L中的3个给体原子和1个甲氧配体的氧原子定义其赤道面,利用1个酮氧原子和1个甲醇氧原子占据其2个轴向位置.本文还研究了这2个配合物对幽门螺旋杆菌脲酶的抑制活性.在浓度为100μmol· L-1时,配合物1和2对脲酶的抑制率分别为(82.0％±2.8％)和(28.2％±1.7％).此外,还做了配合物和幽门螺旋杆菌脲酶的分子对接研究.
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