Five triorganotin 5-methyl-1H-tetrazolyl-1-acetates and 5-amino-1H-tetrazolyl-1-acetates have been synthesized by the reaction of (R3Sn)2O (R=Ph or n-Bu) or Cy3SnOH (Cy=cyclohexyl) with 5-methyl-1H-tetrazolyl-1-acetic acid or 5-amino-1H-tetrazolyl-1-acetic acid.All the complexes were characterized by elemental analysis,IR and multinuclear NMR (1H,13C and 119Sn).Their structures have been confirmed by the X-ray single crystal diffraction analysis,suggesting that they form linkage coordination polymers through the intermolecular Sn… N interactions.The cytotoxic activity of the complexes for Hela and A549 cells was tested,showing that most of them displaved good cytotoxicities for these two cells in vitro.CCDC:1854152,2;1854153,4;1854154,5.%通过5-甲基/氨基-1H-四唑乙酸与(R3Sn)2O(R为苯基或正丁基)及三环己基氢氧化锡的反应,合成了5个三有机锡5-甲基/氨基-1H-四唑乙酸酯.通过核磁,红外及X射线单晶衍射分析,对这些化合物进行了详细的结构表征.结果表明,这些化合物往往通过分子间的Sn…N作用形成配位高分子.初步的生物活性测试表明,这些配合物对Hela和A549细胞具有明显的体外细胞毒性.
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