Objective To observe the relationship between cognitive function and cerebrovascular reactivity (CVR) by transcranial Doppler in mild cognitive impairment(MCI) patients with qi - deficiency and blood - stasis syndrome. Methods Breath - holding test were studied with transcranial Doppler ultrasonography in 75 patients. CVR to apnea was calculated by means of the breath - holding index (BHD in the middle cerebral arteries. Cognitive function and parameter of cerebral hemodynamics were observed under different CVR status, and the effect of vascular risk factor on BHI was analyzed. Results There was correlation between mini - mental state examination (MMSE) with latency of P300 in visual and auditory event - related potentials (ERP) among those patients (r=—0. 512, P<0. 01;r= —0. 547,P<0. 01). Between score of MMSE,P2 - P3 of auditory ERP and latency of P300 in visual ERP,there was positive and negative correlation with BHI respectively. Of all the variables considered, the score of MMSE change had the highest correlation with BHI (r=0. 306,P = 0. 008). Cerebral arteriosclerosis had a remarkable effect on BHI. Conclusion The BHI could provide valuable information included individual patient cognitive state,vascular risk factor to influence the disease progression in MCI with qi - deficiency and blood - stasis syndrome.%目的 观察气虚血瘀型轻度认知障碍(mild cognitive impairment,MCI)患者的脑血管反应性(cerebrovascular reactivity,CVR)与认知功能的关系.方法 应用经颅多普勒超声对75例符合诊断标准的患者进行屏气试验检测,观察不同CVR状态下认知功能及脑血流动力学指标的特点,分析血管性危险因素对屏气指数(breath-holding index,BHI)的影响.结果 简易智能量表(mini-mental state examination,MMSE)分值与听觉、视觉事件相关电位(event-related potentials,ERP)的P300潜伏期有显著相关性(r=-0.512,P<0.01;r=-0.547,P<0.01);BHI与MMSE分值、听觉ERP的P2-P3峰间差呈正相关(P<0.05),BHI与视觉ERP的P300潜伏期呈负相关(P<0.05),其中BHI与MMSE分值的相关性最强(r=0.306,P=0.008);脑动脉硬化对BHI有显著影响.结论 气虚血瘀型MCI患者的认知功能损害与BHI的改变相关,血管性危险因素影响疾病的发生发展过程.
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