Objective To observe the effect of ultrasound-guided radiofrequency ablation (RFA) for the treatment of liver cancer (LC).Methods A total of 165 patients with LC were divided into conservative therapy group (52 patients),operation group (55 patients with 60 lesions) and RFA group (58 patients with 64 lesions).All patients underwent CEUS,CT and/or PET-CT,and liver function,AFP,CEA were compared before and after treatment.Results The hospital stays and hospitalization expense in RFA group were lower than those in the other groups (all P＜0.05).The effective rates were not different between operation group and RFA group 3 months after treatment (P＞0.05),but obviously higher than conservative therapy group (P＜0.05).There were distinct improvement of liver function,AFP and CEA after treatment in all 3 groups,especially in operation group and RFA group.No distinct difference of 2-year survival rate was found between operation group and RFA group (P＞0.05),which were both higher than conservative therapy group (both P＜0.05).Conclusion RFA guided by ultrasound is effective,safe and low cost in the treatment of primary and metastatic liver cancer,particularly in patients being intolerable or unwilling to accept surgical operation and with tumor less than 5 cm.%目的 观察超声引导下射频消融术(RFA)治疗肝癌(LC)的效果.方法 回顾性分析165例LC,其中52例接受保守治疗(保守治疗组),55例(60个肿瘤)接受手术治疗(手术治疗组),58例(64个肿瘤)接受超声引导下射频消融治疗(RFA组),于治疗前后接受CEUS、CT或PET-CT、肝功能、甲胎蛋白(AFP)、癌胚抗原(CEA)等检查,并定期接受临床随访.结果 RFA组患者住院时间和费用明显低于保守治疗组和手术治疗组(P均＜0.05)；治疗后3个月有效率在手术治疗组与RFA组间差异无统计学意义(P＞0.05),但明显高于保守治疗组(P＜0.05)；3组患者的肝功能指标、AFP、CEA均较治疗前明显下降(P均＜0.05),手术治疗组与RFA组优于保守治疗组(P均＜0.05)；2年生存率在手术治疗组与RFA组间差异无统计学意义(P＞0.05),但均明显高于保守治疗组(P均＜0.05).结论超声引导下射频消融治疗原发及转移性LC有效、安全、费用低,特别适用于不能耐受或者不愿手术且直径＜5 cm的肿瘤.
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