目的 探讨血管内皮生长因子(VEGF)、微血管密度(MVD)在外阴上皮内非瘤样病变、外阴上皮内瘤样病变(VIN)及外阴鳞状细胞癌中的表达及其临床意义.方法 采用免疫组织化学方法(S-P法)检测VEGF、MVD在外阴上皮内非瘤样病变40例(包括外阴鳞状上皮细胞增生20例及外阴硬化性苔藓20例)、VIN20例及外阴鳞状细胞癌20例中的表达.结果 VEGF在VIN中阳性表达率为35%,在外阴鳞状细胞癌中阳性表达率为80%,两者间具有显著差异性(P＜0.05 ).MVD在正常外阴皮肤组织中MVD值为20.80,在外阴鳞状上皮增生中MVD值为29.45,在外阴硬化性苔藓中MVD值为17.40,在VIN中MVD值为38.90,在外阴鳞状细胞癌中MVD值为46.85,各组之间具有显著差异(P＜0.05).结论 ①VEGF促进了VIN和外阴鳞状细胞癌新血管生成,在外阴癌变的过程中起到了重要作用.②外阴硬化性苔藓中存在微循环障碍.%Objective To investigate the expressive of VEGF and MVD,and the clinical significance in Nonneoplastic Epithelial Disorders of Vulva、VIN and Vulvar Squam ous Carcinoma.Methods Immunohistochem ical demonstration(S-P) of VEGF and MVD in 40 cases of Nonneoplastic Epithelial Disorders of Vulva(including 20 cases of LS ,20 cases of SH),20 cases of VIN,20 cases of VSCC.Results The positive expression of VEGF in VIN was 35％,In VSCC was 80％,the difference was statistically significant(P ＜0.05 ) .In NS ,MVD value was 20.80; in SH ,MVD value was 29.45; In LS ,MVD value was 17.40; in VIN, ,MVD value was 38.90 ;In VSCC ,MVD value was 46.85 .There was significant difference between every two groups. ( P＜0.05 ) .Conclusion ①VEGF promoted the angiogenesis of VIN and V SCC ,and made an important role in vulvar cancerization .②There was microcirculative handicap h LS.
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