目的：观察中药燕滨扶正胶囊通过调节人体免疫机能对乙型肝炎病毒学指标的疗效。探讨中药治疗乙型肝炎HBsAg、HBeAg滴度的临床疗效。方法将CHB患者随机分为燕滨扶正胶囊组（治疗组，23例）和ADV组（对照组，21例）。治疗组单用燕滨扶正胶囊，1.5 g/次，3次/d，不用任何保肝及抗肝纤维化药物；对照组服用ADV，10 mg/次，1次/d，并根据病情需要加服复方牛胎肝等护肝药物。两组疗程均为48周。结果两组治疗前后HBsAg、HBeAg比较，差异均有统计学意义（P ＜0.05，P ＜0.01）。结论单纯运用中药“燕滨扶正胶囊”可使HBsAg、HBeAg、HBV DNA载量下降，改善脾肿大。%Objective To observe the effect of Yanbinfuzheng capsule against HBV virological indicators by boosting the immune system of patients. Explore the clinical efficacy of traditional Chinese medicine treatment on reducing the HBsAg, HBeAg virus titer and the splenomegaly of hepatitis B disease. Methods Total of the patients were randomly assigned to a treatment group (n = 23) that received Yanbinfuzheng capsule, or to a protocol group (n = 21). The control group alone had Yanbinfuzheng capsule, 5 capsules once time, 3 times once day; the protocol group received 10 mg adefovir dipivoxil once day, in addition, the treatment group received liver function improvement medicine such as Fufangniutaigan according to their situation;however, the treatment group had no such medicine during the clinical trial. Patients in both groups were treated for 48 weeks. Results Groups were similar with respect to demographics, admission criteria, operation type, and other variables. The treatment group had signiifcantly lower HBsAg (P<0.05) and HBeAg (P < 0.01) after the treatment. Conclusions The results showed that solely use of medicine Yanbinfuzheng capsule enables HBsAg, HBeAg HBV DNA splenomegaly load reduction.
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