Objective To compare the value of 99mTc-Octreotide scintigraphy and high-frequency ultrasonography in qualitative diagnosis of thyroid solid and cold nodule. Methods Eighty-two patients with solid nodule confirmed by high-frequency ultrasonography and cold nodule confirmed by thyroid scan were enrolled. All patients underwent 99mTc-Octreotide scintigraphy within 3 days, and the results were compared with those of post-surgery pathology. Results Among 82 patients, there were 31 malignant and 51 benign thyroid nodules. The sensitivity, specificity, positive predicting value, negative predicting value and accuracy rate of 99mTc-Octreotide scintigraphy, high-frequency ultrasonography and combined imaging in detecting thyroid malignant nodules were 70. 97% (22/31), 96.08% (49/51), 91.67% (22/24), 84.48% (49/ 58), 86.59% (71/82); 77.42% (24/31), 84.31% (43/51), 75.00% (24/32), 86.00% (43/50), 81.71% (67/82) and 87. 10% (27/31), 98. 04% (50/51), 96. 43% (27/28), 92. 59% (50/54), 93. 90% (77/82). Conclusion 99mTc-Octreoti-de scintigraphy and high-frequency ultrasonography may both offer good efficacy for qualitative diagnosis of thyroid solid and cold nodule, while 99mTc-Octreotide scintigraphy has higher specificity.%目的 比较99mTc-Octreotide显像与高频超声在甲状腺实性冷结节定性诊断中的价值.方法 对82例高频超声检查为实性结节、甲状腺静态显像呈“冷结节”的患者于超声检查3天内行99mTc-Octreotide显像,并将结果与术后病理结果进行对照.结果 82例患者中,恶性结节31例,良性结节51例.99mTc-Octreotide显像、高频超声及二者联合显像诊断恶性结节的灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为70.97％(22/31)、96.08％(49/51)、91.67％(22/24)、84.48％(49/58)、86.59％(71/82),77.42％(24/31)、84.31％(43/51)、75.00％(24/32)、86.00％(43/50)、81.71％(67/82)及87.10％(27/31)、98.04％(50/51)、96.43％(27/28)、92.59％(50/54)、93.90％(77/82).结论 99mTc-Octreoti-de显像与高频超声均对定性诊断甲状腺实性“冷结节”具有良好效能,而99m Tc-Octreotide显像特异度较高.
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