Objective To explore the value of Tei index, tissue Doppler imaging (TDI) combined with N-terminal proB-NP (NT-proBNP) in evaluating acute radiation induced right heart injury. Methods NT-proBNP and echocardiography were performed in 21 patients underwent thoracic radiotherapy (RT) at the timepoint of before RT, 1 day and 1 month after RT. The following echocardiographic parameters were obtained: ①Tei index; ②Conventional parameters, including the deceleration time of E wave, peak early filling velocity (E) , late diastolic filling velocity (A), E/A ratio and deceleration time of E peak, as well as right ventricular end diastolic diameter, right atrium end systolic diameter, right ventricular fractional area change and tricuspid annular plane systolic excursion;③TDI parameters: Mitral annulus peak velocities in systole (Sa) , early diastole (Ea) , late diastole (Aa). Then the mitral inflow E velocity to tissue Doppler Ea (E/Ea) was calculated. Results Compared with data before RT, NT-proBNP increased 1 day after RT but declined to a low level a month later (P<0. 05) , while Sa and Ea decreased, Tei index, Aa and E/Ea increased, but conventional parameters had no significant changes (all P>0. 05). Conclusion After RT, TDI, Tei index and NT-proBNP can provide valuable information for evaluating acute radiation induced right heart injury.%目的 探讨Tei指数和组织多普勒成像(TDI)联合N端B型钠尿肽前体(NT-proBNP)评价胸部肿瘤患者放疗后右心早期损伤的价值.方法 对21例接受胸部全程放疗的胸部肿瘤患者,于放疗前、放疗后1天和1个月行NT-proBNP和超声心动图检查,检查指标:①Tei指数；②常规指标,包括三尖瓣血流舒张早期峰值流速(E)、心房收缩期峰值流速(A)、E/A和E峰减速时间；右心室舒张末期内径和有心房收缩末期内径,右心室面积变化率及三尖瓣瓣环运动幅度；③TDI:三尖瓣环内侧和外侧处收缩期峰值速度(Sa)、舒张早期峰值速度(Ea)、舒张晚期峰值速度(Aa)及E/Ea.结果 与放疗前相比,NT-proBNP在放疗后1天明显升高(P＜0.05),放疗后1个月降低；放疗后Tei指数升高,Sa、Ea减低,Aa和E/Ea均升高；常规指标在放疗前后无明显变化.结论 胸部肿瘤患者放疗后出现右心功能早期轻度损伤；Tei指数、DTI联合NT-proBNP可对其进行评价.
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