Objective To investigate the correlation of apparent diffusion coefficient (ADC) value of hippocampus with the volume and magnetic resonance spectroscopy (MRS) of hippocampus in patients with hippocampal sclerosis (HS), and to evaluate the diagnostic value of ADC value. Methods Thirteen HS patients (HS group) of unilateral temporal lobe epilepsy (TLE) and 20 age-matched healthy subjects (control group) were studied with hippocampal ADC maps, volume measurement of hippocampus and N-acetylaspartate to choline and creatine ratios [NAA/(Cho+Cr)]. The ADC values of bilateral hippocampi and asymmetry index (AI, including AIADC, AIVOLUME and AIMRS) were measured respectively, and the correlations of ADC value with other quantitative MR measurements, age at onset and duration of epilepsy were evaluated.Results The ADC value in ipsilateral hippocampus was higher than that in contralateral side and the control group (both P ＜0. 001 ), and AIADC in patients with HS was also higher than that in the control group (P＜0. 001). Significant correlations were found between ADC value and the volume of ipsilateral hippocampus (r=-0.854, P＜0. 001), also between AIADC and AIVPLUME (r=0. 611, P＜0. 05). AIADC showed positive correlation with the duration of epilepsy in HS patients (r=0. 676, P＜0. 05). Conclusion The ADC value of hippocampus is helpful for the preoperative diagnosis of HS and has certain correlation with volume measurement and duration of epilepsy.%目的 探讨海马硬化(HS)患者的海马表观扩散系数(ADC)值与海马体积及磁共振波谱的相关性,并评价ADC值在HS诊断中的价值.方法 对13例单侧颞叶癫痫HS患者(HS组)和20名健康志愿者(正常对照组)行常规MR及磁共振扩散加权成像(DWI)检查,并对HS患者进行海马体积测量和磁共振波谱(MRS)检查,计算双侧海马的ADC值、标准化体积、N-乙酰天门冬氨酸/(胆碱+肌酸)[NAA/(Cho+Cr)]及不对称指数(AI,包括AIADC、AIVOLUME及AIMRS),评价海马ADC值与体积、磁共振波谱、患者发病年龄和病程间的相关性.结果 HS组患侧海马ADC值显著高于健侧海马及正常对照组(P均＜0.001),且HS组海马AIADC显著高于正常对照组(P＜0.001).HS组患侧海马ADC值与海马体积之间存在相关性(r=-0.854,P＜0.001),患者海马AIADC与AIVOLUME之间也存在显著相关性(r=0.611,P＜0.05).HS组海马AIADC与病程长短存在显著正相关(r=0.676,P＜0.05).结论 测量海马ADC值有助于HS的术前诊断.HS患者海马的ADC值与海马体积及病程显著相关.
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