Objective To explore the brain mechanism of arousal abnormal in emotional processing in abstinent heroin abstainer. Methods Totally 13 heroin abstainers (experimental group) and 13 healthy subjects (control group) underwent fMRI when viewing pictures with different arousal levels. Then the arousal ratings were evaluated by the subjects. fMRI data were processed with AFNI software. Behavioral data were analyzed with SPSS 13.0 software. Results Looking at emotional pictures, compared with control subjects, brain activation of experimental group decreased in left amygdale and hippocampus, bilateral thalamus, cingulate gyrus, bilateral superior frontal gyrus and middle frontal gyrus, right precen-tral gyrus, bilateral superior temporal gyrus, right inferior tempotal gyrus, left fusiform gyrus and bilateral caudate nucleus. ROI analysis indicated increased brain activation in experimental group when watching high arousal stimuli than low arousal stimuli in right thalamus, left amygdale and hippocampus, while the controls showed the opposite pattern. Conclusion Heroin abusers have abnormalities in arousal processing.%目的 探讨海洛因成瘾戒断者情绪加工中唤醒度异常的脑机制.方法 通过呈现不同唤醒度的情绪图片对13例海洛因成瘾戒断者(试验组)和13名健康人(对照组)进行fMRI.扫描结束后受试者对图片进行唤醒度评定.利用AFNI软件对脑功能数据进行处理,使用SPSS 13.0统计软件对行为学数据进行分析.结果 观看情绪图片时,试验组左侧杏仁核和海马、双侧丘脑、扣带回、双侧额上回、额中回、右侧中央前回、双侧颞上回、右侧颞下回、左侧梭状回、双侧尾状核等脑区的激活低于对照组；观看高唤醒度图片时,其右侧丘脑、左侧杏仁核和海马的激活高于观看低唤醒度图片,对照组相反.结论 海洛因成瘾者的情绪唤醒度加工机制存在损伤.
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