Purpose Protein is the main influencing factors for diffusion weighted imaging (DWI) signals and apparent diffusion coefficient (ADC), it results in hyperintensity on DWI and low ADC, but not fully matched in clinic. This paper aims to investigate the effect of protein type and concentration on the signal intensity (SI) and ADC of DWI. Materials and Methods Different concentrations of albumin, globulin solution and the mixed solution were created in vitro. DWI was performed on GE 1.5T superconducting nuclear MRI system. Results ① There was a linear negative correlation between the ADC value and the concentrations of protein solution (at 37℃, ra= - 0.849, Pa<0.05; rg= - 0.843, Pg<0.05; at 40℃, ra= - 0.894, Pa<0.05; rg= - 0.819, Pg<0.05);there was a linear positive correlation between the SI of DWI and the concentrations of the albumin solution (at 37℃, r=0.753, P<0.05; at 40℃, r=0.845, P<0.05). There was no correlation between the SI of DWI and the concentrations of the globulin solution (at 37℃, r= - 0.222, P>0.05; at 40℃ , r= - 0.270, P>0.05). ② SI of the albumin solution was significantly higher than the globulin solution at the same concentration and temperature (t=3.96, P<0.001); the ADC values were not statistically different between the albumin and the globulin solution (t=0.61, P>0.05). Conclusion The nature of the cystic fluid can be understood preliminarily through quantitative analysis of the cystic fluid DWI and ADC values, so as to provide theoretical basis for the qualitative diagnosis of cystic lesions in vivo.%目的蛋白质是影响扩散加权成像（DWI）信号及表观扩散系数（ADC）值的主要因素，使囊液于 DWI 上呈高信号，ADC 值降低，但在实际工作中并非完全如此，本研究拟深入了解蛋白质的类型、浓度对其的影响。材料与方法通过在体外制作不同浓度的白蛋白溶液、球蛋白溶液及同浓度不同比例的白蛋白和球蛋白混合溶液体模，采用 GE 1.5T 超导型 MRI 成像系统，定量研究其对 DWI 信号和 ADC值的影响。结果① ADC 值与白蛋白及球蛋白溶液浓度呈线性负相关（37℃时，r 白=－0.849，P 白<0.05；r 球=－0.843，P 球<0.05；40℃时，r 白=－0.894，P 白<0.05；r 球=－0.819，P 球<0.05）；DWI 信号强度与白蛋白溶液的浓度呈线性正相关（37℃时， r=0.753，P<0.05；40℃时，r=0.845，P<0.05），而与球蛋白溶液的浓度无相关性（37℃时，r=－0.222，P>0.05；40℃，r=－0.270，P>0.05）。②相同浓度和温度下，白蛋白溶液 DWI 信号强度高于球蛋白溶液（t=3.96，P<0.001），ADC 值差异无统计学意义（t=0.61，P>0.05）。结论通过对囊液 DWI 及 ADC 值的定量分析，可以初步了解囊液的性质，从而为体内囊性病变的定性诊断提供理论依据。
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