Purpose To discuss the clinical application of different reconstructive R-R intervals and slice thicknesses to assess left ventricular global function using dual-source computed tomography (DSCT). Materials and Methods Thirty healthy adults underwent dual-source CT coronary angiography (DSCTA). Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were measured using full cardiac phase reconstruction of different R-R intervals (1%, 5%, 10%) and slice thicknesses (1 mm, 2 mm, 3 mm, 4 mm, 5 mm) respectively. Results There was no significant difference in EDV, ESV, SV and EF among groups with different slice thicknesses (P>0.05). When 4 mm or more slice thickness was chosen, it was difficult to delineate endocardial and epicardial left ventricular contours. There was no significant difference in EDV, ESV, SV and EF among groups with different R-R intervals (P>0.05). The measurements in groups using 1%R-R interval were slightly higher than that using 10%R-R interval, the reconstructive time of 10%R-R interval was the shortest among three groups, but no statistical difference was shown among different groups (P>0.05). Conclusion DSCT coronary artery angiography can evaluate the degree of coronary stenosis and left ventricular function using different R-R intervals and slice thicknesses. 3 mm slice thickness and 10% R-R interval reconstruction are sufficient to accurately evaluate left ventricular function and are also more time-effective.% 目的探讨双源CT（DSCT）不同R-R间期间隔及不同重建层厚评价左心室整体功能的临床价值。资料与方法30例临床健康体检者，分别以1%、5%及10%R-R间期间隔重组获得全心动周期图像；不同重建层厚（1、2、3、4、5 mm）全时相重建，并测定各间期及不同重建层厚左心室舒张末期容积（EDV）、收缩末期容积（ESV）、每搏输出量（SV）、左心室射血分数（LVEF）。结果①分别采用不同重建层厚进行心功能分析时，不同间隔组间测得心功能结果比较差异无统计学意义（P>0.05）。当层厚选择4 mm以上时心室内外膜边界模糊，勾画时有困难。②采用不同R-R间期间隔重建行心功能分析，1%R-R间期间隔EDV、SV、LVEF稍高于10%，10%间隔重建用时最短，但不同间隔组间比较差异无统计学意义（P>0.05）。结论DSCT冠状动脉造影同时可以评估左心整体功能，不同层厚、不同R-R间期间隔重组均能准确评价左心功能，但以3 mm层厚、10%R-R间期间隔重组相对方便快捷，具有重要的临床实用价值。
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