首页> 中文期刊> 《中国新生儿科杂志》 >超早产儿/超低出生体重儿自发性肠穿孔危险因素分析

超早产儿/超低出生体重儿自发性肠穿孔危险因素分析

         

摘要

Objective To analyse the risk factors associated with spontaneous intestinal perforation (SIP) in extremely premature infants/extremely low birth weight infants. Method From January 2015 to December 2018, infants with gestational age (GA)<28 weeks or birth weight (BW)<1000 g admitted to our neonatal intensive care unit were enrolled to the retrospective nested case-control study.The clinical data of SIP infants (SIP group) and infants with the same GA but without SIP (control group) were randomly selected and compared. Multivariable Logistic regression was used to analyse the risk factors of SIP. Result A total of 409 extremely premature infants/extremely low birth weight infants were born during the study period. Among them, 25 SIP infants and 55 controls were enrolled. The incidence of SIP in infants with GA 22~25 weeks was 11.8%(16/136), which is higher than infants with GA 26~27 weeks (2.0%, 5/247) (χ2=16.057, P<0.001). The incidence of SIP in infants with BW 400~749 g was 13.0%(14/108), which is higher than infants with BW 750~999 g (3.4%, 8/236) (χ2=11.343, P=0.001). Multivariate Logistic regression analysis showed that twins (OR=4.153, 95%CI 1.392~12.384, P=0.011), umbilical veins catheterization (OR=15.942, 95%CI 1.026~247.789, P=0.048) and ibuprofen use within 3 days after birth (OR=15.387, 95%CI 1.519~155.883, P=0.021) were independent risk factors of SIP. Conclusion The smaller the GA and BW, the higher the incidence of SIP. Twins,umbilical veins catheterization and ibuprofen use early after birth may be independent risk factors of SIP.%目的 探讨超早产儿/超低出生体重儿自发性肠穿孔(spontaneous intestinal perforation,SIP)的危险因素.方法 采用回顾性巢式病例对照研究设计,纳入南方医科大学附属深圳妇幼保健院新生儿重症监护病房2015年1月至2018年12月收治的胎龄<28周或出生体重<1000 g的早产儿,其中诊断SIP早产儿为SIP组,按约1:2的比例随机抽取同期、同胎龄、无肠穿孔早产儿为对照组,比较两组母孕期和新生儿期特点,多因素Logistic回归分析SIP的危险因素.结果 研究期间共收治胎龄<28周或出生体重<1000 g的早产儿409例,其中纳入SIP组25例,对照组55例.胎龄22~25周早产儿SIP发生率11.8%(16/136),26~27周为2.0%(5/247),差异有统计学意义(χ2=16.057,P<0.001).出生体重400~749 g早产儿SIP发生率13.0%(14/108),750~999 g为3.4%(8/236),差异有统计学意义(χ2=11.343,P=0.001).多因素Logistic回归分析显示,双胎(OR=4.153,95%CI 1.392~12.384,P=0.011)、脐静脉置管(OR=15.942,95%CI 1.026~247.789,P=0.048)、生后3 d内开始口服布洛芬(OR=15.387,95%CI 1.519~155.883,P=0.021)是超早产儿/超低出生体重儿SIP的独立危险因素.结论 胎龄越小、出生体重越低,SIP发生率越高.双胎、脐静脉置管、生后早期口服布洛芬可能是SIP的危险因素.

著录项

  • 来源
    《中国新生儿科杂志》 |2019年第5期|358-362|共5页
  • 作者单位

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

    南方医科大学附属深圳妇幼保健院新生儿科 518028;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类
  • 关键词

    肠穿孔; 婴儿,超低出生体重; 超早产儿; 危险因素;

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