缺氧诱导因子1(hypoxia-inducible factor 1,HIF-1)是组织和细胞对低氧环境反应的主要蛋白.HIF-1参与急性肾损伤及慢性肾脏病等疾病.已有研究发现,HIF-1可通过直接调控基因表达,调节下游靶基因,参与信号通路、表观遗传学修饰参与肾脏疾病的发展,但是现在对HIF-1参与肾脏疾病的机制尚不完全清楚.本文就HIF-1在肾脏疾病中的作用和机制作一总结,为其临床和基础研究奠定基础.%Hypoxia-inducible factor 1 (HIF-1) is a master regulator switch for the adaptive response to cellular and tissue hypoxia.It has been reported to participate in various kidney diseases,including acute kidney injury (AKI),chronic kidney disease (CKD).Previous studies have shown that HIF-1 could regulate development of renal disease by transcriptional regulation of downstream target genes,interacting with other signaling pathways and epigenetic modifications of the genome.This paper will summarize the role of HIF-1 in kidney diseases and the underlying mechanisms.
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