Sepsis is a major cause of acute kidney injury (AKI) with high morbidity and mortality.The mechanism of septic AKI is complicated and poorly illustrated,while no effective etiological treatment is available.Studies regarding novel therapeutic targets for septic AKI are in need.Recent researches have revealed that mitochondrial dysfunction is profoundly involved in the pathophysiology of sepsis as well as septic AKI,which might be a promising target of intervention.In this review,we summarized the progress in the understanding towards septic AKI and mitochondrial dysfunction for the reference of whom it may concern.%脓毒症的发病率和死亡率较高,也是急性肾损伤(AKI)重要原因之一.脓毒症所致AKI发病过程复杂,发病机制尚未完全阐明,迄今缺少有效的防治手段,亟待寻找新的治疗靶点.近来研究表明,在脓毒症性AKI发病的许多环节都与线粒体有关,线粒体功能障碍在脓毒症多器官衰竭尤其是肾脏损伤中扮演着重要角色,并有望成为未来的治疗靶点.本文主要就脓毒症所致AKI线粒体功能障碍的研究进展做一综述,以期为其诊防治提供新思路.
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