Calcineurin inhibitor ( CNI) is a mainstay of immunosuppressant agents for most solid organ transplant patients. Tacrolimus,which is widely used,has a narrow therapeutic range and its pharmacokinetic variability complicates its daily dose assessment. One of tacrolimus' major side effect is nephrotoxicity. Several genes involve in the metabolism of tacrolimus, but whether the genetically polymorphisms play a role in tacrolimus' chronic nephrotoxicity remains unknown.%以他克莫司为代表的神经钙蛋白抑制剂是实体器官移植免疫抑制方案的重要组成部分,被广泛应用于临床.他克莫司治疗窗狭窄,药物浓度个体差异大,因此,肾毒性是其主要的药物不良反应之一.多种基因参与他克莫司的药代动力学和药效动力学过程,但这些基因的多态性是否与他克莫司慢性肾毒性相关至今尚无定论.本文就这方面的研究做一综述.
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