Objective To find frontal lobe-amygdala functional connections in different age paragraph female patients with bipolar disorder. Methods The FMRI date were acquired from 30 patients with bipolar disorder aged 13 to 25 years old and 30 age-and education level-and gender-matched health controls.FMRI was also conducted on 30 patients with bipolar disorder aged 26 to 45 years old and 30 age-and education level-and gender-matched health controls.The date was calculated by using MATLAB based DPARSF software. Results Compared with corresponding health controls, the lobe-amygdala functional connections significantly decreased in patients aged 13 to 25 years but remained unchanged in patients aged 26 to 45 years old. Conclusions The decrease in the frontal lobe-amygdala functional connections decreased in female patients aged 13 to 25 years old may be related to the underdevelopment in vulnerable immature brain.In contrast, the frontal lobe-amygdala functional connections in female patients aged 26 to 45 years old remain intact.%目的 探讨不同年龄阶段女性双相障碍患者前额叶—杏仁核神经环路功能连接的改变. 方法 纳入年龄13~25岁的双相障碍(bipolar disorder,BD)患者30例及年龄、受教育程度相匹配的健康对照30名;年龄26~45岁的BD患者30例及年龄、受教育程度相匹配健康对照30名.选取脑部双侧杏仁核为种子点,应用静息态功能磁共振,分别进行两年龄阶段BD患者组与相应对照组前额叶—杏仁核神经环路功能连接的比较. 结果 与相应对照比较,13~25岁女性BD患者前额叶—杏仁核神经环路功能连接在左侧额中回、左侧眶部额下回、左侧岛盖部额下回及双侧三角部额下回降低(P<0.001,GRF校正).与相应对照比较,26~45岁女性患者前额叶—杏仁核的功能连接差异无统计学意义(P=0.001,GRF校正). 结论13~25岁女性BD患者前额叶—杏仁核神经环路功能连接降低,可能与25岁前大脑发育不完全,存在易损性有关;26~45岁女性BD患者大脑功能可能在此环路中无受损.
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