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首页> 外文会议>International IEEE/EMBS Conference on Neural Engineering >Study of intrinsic functional connectivity from medial prefrontal cortex in female with major depressive disorders
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Study of intrinsic functional connectivity from medial prefrontal cortex in female with major depressive disorders

机译：女性抑郁症重症患者前额叶内侧皮层固有功能连接的研究

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摘要

Major depressive disorder (MDD) is associated with excessive self-focus and a tendency to engage in self-reflection. Women are more inclined to form negative thoughts when facing problems such as social rejection. The neuroimaging studies addressing MDD females are still rare. The medial prefrontal cortex, a central node of anterior default mode network (DMN), plays an important role in the pathophysiology of MDD. In this study, we explored the inter-regional correlation feature of mPFC with whole brain through functional connectivity (FC) analysis of resting state functional magnetic resonance imaging (rs-fMRI) data. Increased FC with left anterior cingulate cortex (ACC_L) was found in female MDD patients compared with healthy controls. Furthermore, the FC strength of ACC_L was positively correlated with clinical scores, which implied the important role of mPFC-ACC pathway in MDD females. Moreover, decreased FC with right middle temporal gyrus (mTG_R) and left middle temporal gyrus (mTG_L) was found in MDD females, which may result from the low self-evaluation in MDD. This work provides additional insights in understanding the pathophysiological mechanisms of MDD women.
机译：严重的抑郁症（MDD）与过度的自我专注和自我反思的倾向有关。妇女在面对诸如社会排斥之类的问题时更倾向于形成消极思想。针对MDD女性的神经影像学研究仍然很少。内侧前额叶皮层（前默认模式网络（DMN）的中心节点）在MDD的病理生理中起重要作用。在这项研究中，我们通过静止状态功能磁共振成像（rs-fMRI）数据的功能连接（FC）分析，探索了mPFC与全脑的区域间相关特征。与健康对照组相比，女性MDD患者发现左前扣带回皮层（ACC_L）的FC增加。此外，ACC_L的FC强度与临床评分呈正相关，这暗示了mPFC-ACC通路在MDD女性中的重要作用。此外，在MDD女性中发现右中颞回（mTG_R）和左中颞回（mTG_L）的FC降低，这可能是由于MDD的自我评价低所致。这项工作为了解MDD妇女的病理生理机制提供了更多的见解。

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