MicroRNAs(miRNAs)是一类长18~25个核苷酸的单链非编码小分子RNA,属于表观遗传学范畴,广泛存在于真核细胞中,通过其表达量的上调和下调,影响细胞分化、增殖、凋亡,肿瘤发生,机体代谢以及衰老等生命过程.近年来有研究发现,miRNAs在眼部的晶状体中也有表达,其表达量的异常可能与年龄相关性白内障(ARC)有密切关系.本文主要就miRNAs与ARC相关性的研究进展作一综述.%MicroRNAs(miRNAs), widely presented in eukaryotic cells, are a class of single strand (18-25 nucleotides), non-coding, small RNA molecules, belonging to the domain of epigenetics .They play a critical role in a series of life processes, including cell differentiation, proliferation, apoptosis, tumorigenesis, individual metabolism and senescence by changing their expression levels .Recent studies have identified some miRNAs in the lens , whose aberrant expressions may be closely associated with the age-related cataract ( ARC) .This article mainly reviewed the advances in the research of correlation between miRNAs and ARC .
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