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首页> 中文期刊> 《有机化学》 >Novel Base-Promoted Syntheses ofβ-Indolylketones via a Three- Component Condensation under Ultrasound Irradiation

Novel Base-Promoted Syntheses ofβ-Indolylketones via a Three- Component Condensation under Ultrasound Irradiation

         
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摘要

In recent years, a wide variety of organic compounds bearing indole fragment have been attracted much attention due to the fact that many of them are pharmacologically and biologically active compounds.[1] Among them β-indolylketones are one of the most significant intermediates for the preparation of natural products such as hapalindole D 1.[2] In recent years, the utilization of multicomponent condensations (MCCs) to generate novel, drug-like scaffolds are replete in current organic reactions due to the fact that products can be prepared directly in a single step and the diversity can be achieved simply by varying the reaction substrates. In continuation of our work to synthesize new β-indolylketones,[3] herein, we report a novel base-induced syntheses of new β-indolylketones via a three-component condensation. Deoxybenzoin as carbonyl compound is introduced into the reaction (Scheme 1), and all the reactions were operated under ultrasound irradiation since the utilization of which can accelerate the progress of many reactions and shorten the reaction time.……

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  • 来源
    《有机化学》 |2004年第z1期|259|共1页
  • 作者

    SHEN; Zhi-Liang WANG; Shun-Yi JI; Shun-Jun;

  • 作者单位

    Key Laboratory of Organic Synthesis of Jiangsu Province;

    College of Chemistry and Chemical Engineering;

    Suzhou University;

    Suzhou 215006 Key Laboratory of Organic Synthesis of Jiangsu Province;

    College of Chemistry and Chemical Engineering;

    Suzhou University;

    Suzhou 215006 Key Laboratory of Organic Synthesis of Jiangsu Province;

    College of Chemistry and Chemical Engineering;

    Suzhou University;

    Suzhou 215006;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 有机化学;
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