AIM:To analyze the effect of non-exchange transfusion therapy, including simple phototherapy or phototherapy combined with albumin therapy, on severe jaundice in full-term neonates.METHODS: The full-term neo-nates (n=110) with serum total bilirubin (TBIL) level over 342 μmol/L recewed simple phototherapy or phototherapy combined with albumin therapy.The changes of serum bilirubin levels and neurological signs of these neonates were ob-served.RESULTS:Serum TBIL and indirect bilirubin ( IBIL) levels in the 2 groups of hospitalized cases significantly re-duced after the first day of treatment and at discharged (P<0.01).The reduced degrees of TBIL and IBIL levels in the neonates given phototherapy combined with albumin therapy were higher than those in the neonates given simple photothera-py.All these neonates did not have bilirubin encephalopathy on admission or at discharged.CONCLUSION:Both simple phototherapy and phototherapy combined with albumin therapy treat severe jaundice effectively and prevent acute bilirubin encephalopathy in full-term neonates.%目的：分析非换血治疗（包括单纯光疗和光疗联合白蛋白治疗）对足月新生儿重度黄疸的治疗效果。方法：回顾分析110例接受单纯光疗或光疗联合白蛋白治疗、血清总胆红素水平＞342μmol／L的足月新生儿。观察患儿血清胆红素水平变化及神经系统体征。结果：单纯光疗组和光疗联合白蛋白治疗组患儿在治疗第1天后及出院时其血清总胆红素及间接胆红素水平均显著下降（ P＜0.01）。光疗联合白蛋白治疗组患儿较单纯光疗组患儿出院时血清总胆红素及间接胆红素水平降低程度更高。所有患儿入院及出院时均未发生胆红素脑病。结论：单纯光疗和光疗联合白蛋白治疗均可以有效治疗足月新生儿重度黄疸，预防急性胆红素脑病。
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