AIM: To explore the effect of bone marrow-derived mesenchymal stem cells (BMSCs) combined with vitamin E on the inflammatory reaction in acute kidney injury ( AKI) rats.METHODS:Gentamicin was used to in-duce AKI and the rats were treated with BMSCs combined with vitamin E.After treatment, the rat plasma and kidney tis-sues were collected, and the expression of inflammatory factors at mRNA and protein levels was detected by real-time quan-titative PCR and ELISA.RESULTS:After the treatment with BMSCs combined with vitamin E, the inflammatory proteins were down-regulated in the plasma and the renal tissues.Compared with single treatment group, the decreases in the in-flammatory proteins were more obvious in combined treatment group.CONCLUSION: The method of BMSCs combined with vitamin E takes the anti-inflammatory effect on AKI, indicating a new and potential mode in clinical application for AKI therapy.%目的：探索骨髓间充质干细胞联合维生素E对急性肾损伤中炎症反应的抑制效果，开发针对急性肾损伤的新型治疗模式。方法：采用庆大霉素作为急性肾损伤药物，复制大鼠急性肾损伤模型，以骨髓间充质干细胞联合维生素E对急性肾损伤进行治疗，治疗结束后，收集大鼠的血浆和肾脏组织，采用实时荧光定量PCR及ELISA方法，评价血浆及组织中炎症蛋白的表达。结果：通过骨髓间充质干细胞联合维生素E对大鼠急性肾损伤模型进行治疗后，大鼠血浆中的炎症蛋白显著降低；在肾脏组织中，与单一应用骨髓间充质干细胞或维生素E相比，二者联合在某些炎症蛋白的抑制方面具有更明显的效果。结论：骨髓间充质干细胞联合维生素E对急性肾损伤中炎症反应具有一定抑制效果，优于单一骨髓间充质干细胞或单一维生素E的治疗方式，所以，这种联合治疗模式在急性肾损伤的治疗方面更具有临床应用价值。
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