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首页> 中文期刊> 《中国病理生理杂志》 >增强型体外反搏增加心脏骤停犬颈总动脉血流量

增强型体外反搏增加心脏骤停犬颈总动脉血流量

         
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目的:探讨增强型体外反搏(EECP)干预对心脏骤停(SCA)犬颅内压(ICP)、脑灌注压(CPP)和右颈总动脉平均流量(MQ)的影响.方法:12只犬制成SCA模型,经心肺复苏至自主循环恢复(ROSC)后随机分成对照组(4只)和EECP组(6只),2只建模未成功.EECP组分别行2次1 h EECP干预,观察致颤前后、ROSC后(每1 h)ICP、CPP和MQ的变化,ROSC 6 h后停止监测.结果:平均动脉压(MBP)、收缩期血压峰值(MSP)、ICP、平均脑灌注压(MCPP)和收缩期脑灌注压峰值(SCPP)组间比较差异无统计学意义(P＞0.05);EECP时舒张期血压峰值(MDP)和舒张期脑灌注压峰值(DCPP)明显高于对照组(P＜0.05).EECP组颈总动脉血流阻力在EECP时明显低于对照组(P＜0.05).EECP时MQ明显高于对照组(P＜0.05).结论:EECP并不影响SCA-ROSC模型MBP、MSP、ICP、MCPP和SCPP而是通过增加MDP、DCPP和降低血流阻力等机制来增加颈总动脉的平均血流量.%AIM: To invesligale the effecls of enhanced exlernal counlerpulsalion (EECP) on inlracranial pressure (ICP) , cerebral perfusion pressure ( CPP) , common carolid arlery blood flow following sudden cardiac arresl (SCA) and successful relurn of spontaneous circulation ( ROSC) by cardiopulmonary resuscilalion ( CPR) in dogs. METHODS; Dog SCA model was induced with alternating current, then 10 dogs were randomly divided into EECP group (re =6) and control group (re =4) after successful ROSC. The arterial blood pressure (BP) , quantity of right common carotid artery blood flow (Q) and intracranial pressure (ICP) were measured. Cerebral perfusion pressure (CCP) equaled to BP minus ICP. Resistance of common carotid artery equaled to mean BP/mean Q. RESULTS: The animal model of SCA - ROSC in 10 dogs were successfully established. No significant difference of mean blood pressure ( MBP) , maximum systolic pressure (MSP) , mean ICP, systolic ICP, diastolic ICP, mean CPP and maximum systolic CPP at all time points between the 2 groups was observed. Compared with control group, the maximum diastolic pressure ( MDP) and maximum diastolic CPP was significantly elevated, the resistance of common carotid artery was significantly decreased, and right common carotid artery blood flow was significantly increased in EECP group. CONCLUSION; EECP does not affect MBP, MSP, ICP, mean CPP and systolic CPP,but improves common carotid artery blood flow possibly by increasing diastolic BP, diastolic CPP and reducing the resistance of common carotid artery or other mechanisms.

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