Mortalin( mtHSP70/HSP75/(Grp75/TRAP - 1/PBP74 ) is an essential mitochondrial chaperone and is helieved to regulate multiple cellular functions ranging from cell survival, cell proliferation, stress response, mitochondrial biogenesis and intracellular trafficking.Recent studies have shown that mortalin is relevant to the pathogenesis of Alzheimer's disease( AD ) and Parkinson's disease( PD ).Proteomic studies demonstrate the differential expression of mortalin not only in the models of AD or PD hut also in PD human hrains as compared to the controls.Mortalin seems to modulates the development of diseases through association with the critical molecules such as apoE, amyloid β - protein , amyloid precursor protein( APP ) in AD, and α - synuclein, DJ - 1, PINK1 in PD.Mortalin may regulate PD development via the pathways involving mitochondrial and proteasomal functions as well as oxidative stress.Furthermore , it is reported that mortalin participates in the pathological processes of several other neurological disorders, such as ischemic brain injury, absence seizure and Friedreich's ataxia( FRDA ).%@@ 1993年,Wadhwa等[1]在小鼠胚胎成纤维细胞(mouse embryonic fibroblasts, MEF)中首次克隆出了Mortalin(mtHSP70/HSP75/Grp75/TRAP-1/PBP74),它是热休克蛋白70(heat-shock protein 70, HSP70)家族成员之一.研究表明,Mortalin参与了多种生理功能的调控,包括细胞存活、细胞增殖、压力应激、线粒体合成、细胞内转运等,并且可能在神经系统疾病中发挥作用.在此,本文就Mortalin的基本结构、生理功能以及与神经系统疾病尤其是神经退行性疾病的相关性作一个综述.
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