Obje ctive To investigate the occurrence of adverse reactions induced by ibuprofen in children in our hospital, so as to provide evidence for rational drug use in clinic. Me thods 105 cases of adverse drug reactions in children treated with ibuprofen in our hospital from 2000 to 2018 were collected and analyzed according to sex, age, drugs, adverse reactions types and clinical manifestations. Re s ults The adverse drug reactions of ibuprofen were related to dosage, course of treatment and combined use of drugs. Allergic reaction was the main clinical manifestation, and anaphylactic shock could occur. Conclus ion Attention should be paid to the adverse drug re actions of ibuprofen in children, especially in children aged 0 ～6 years, and rational use of ibuprofen should be strictly in accordance with the labelling.%目的 探讨我院儿童使用布洛芬所致不良反应发生情况,为临床合理用药提供依据.方法 收集2000～2018年我院儿童使用布洛芬发生不良反应报告105例,按照性别、年龄、使用药物、不良反应类型、临床表现等进行统计分析.结果 布洛芬不良反应与用药剂量、疗程及合并用药等因素有关,临床表现以变态反应为主,严重可出现过敏性休克.结论 应重视儿童使用布洛芬的不良反应,尤其是0～6岁儿童,需严格按照药品说明书合理用药.
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