Objective To explore the expression of Galectin-1 and its relationship with HR-HPV in cervical cancer. Method Immunohistoehemistiy S-P assay was used to detect the expression of Galectin-1 in 54 patients with cervical cancer, 35 patients with CIN and 20 patients with normal cervix. And HR-HPV infection levels were detected by HC- II before operation. Results The rates of Galectin-1 expression were 5.0% (1/20) , 15. 0% (3/20) , 53. 3% (8/15) and 48. 1% (26/54) in patients with normal cervix,CIN I - II ,CINM and cervical cancer respectively. The rate of Galectin-1 in the cervical tissues at the advanced stages (stages HI -IV, 81.3%) was higher than that at the early stages (stages I ~ II , 34. 2% , P <0. 05). In cervical cancer, the galectin-1 positive expression was correlated with lymph node metastasis (P < 0. 05 ) , higher histological grade (P < 0. 05 ) , clinical stage (P < 0. 01) and HR-HPV positive expression ( P <0.05 ). However, there was no significant association between the tissues of squamous cervical cancers and ade-nocarcinoma. Conclusion Galectin-1 may play vital roles in tumor genesis and development of the HR-HPV related cervical cancer.%目的 探讨半乳糖凝集素-1(Galectin-1,Gal-1)在宫颈癌的发生、发展中作用及与高危型HPV的关系.方法 免疫组织化学法检测柳州市人民医院2007年2月至2009年2月54例宫颈癌、35例宫颈上皮内瘤样病变(CIN)和20例宫颈正常组织中Gal-1蛋白的表达；并用HC-Ⅱ法检测高危型人乳头状瘤病毒(HR-HPV)感染情况.结果 Gal-1在正常宫颈、CIN Ⅰ～Ⅱ、CINⅢ和宫颈癌组织中的阳性表达率分别为5.0％、15.0％、53.3％、48.1％；晚期宫颈癌组织中Gal-1的表达率(83.1％)明显高于早期宫颈癌中的表达率(34.2％).宫颈癌中Gal-1 阳性表达与淋巴结转移(P＜0.05)、肿瘤低分化(P＜0.05)、临床分期(P＜0.01)和HR-HPV的感染(P＜0.05)有关,但与宫颈癌组织学类型无关.结论 Gal-1可能在宫颈癌的发生、发展中起着重要作用,HR-HPV可能通过诱导宫颈上皮高表达Gal-1而促使宫颈癌发生发展.
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