目的 提高对巨大淋巴结增生症(CD)的认识.方法 收集中南大学湘雅二医院1996年1月至2008年5月27例经病理学确诊的CD患者资料,分为局灶(LCD)组和多中心(MCD)组.从临床表现、病理分型、治疗等方面进行回顾性分析和总结.结果 CD的严重程度和对治疗的反应与临床和病理学分型相关,MCD和浆细胞型往往预 后较差.结论 LCD和MCD是拥有不同临床表现和预后的同一疾病的两种不同类型,其在发病机制和伴发疾病上有所差异.诊断时区分亚型是十分必要的.%Objective To broaden our horizon with regard to lymphadenomegaly ( Castleman's disease). Methods The clinical profiles of 27 patients with confirmed Castleman's disease (CD) via pathological biopsy in The Second Xiangya Hospital of Central South University from January 1996 to May 2008 were gathered. All patients were assigned to local Castleman's Disease (LCD) group and multicentre Castleman's Disease (MCD) group. Retrospective analyses and reviews were performed on clinical manifestations, histopathologic subtypes and treatment. Results The severity of Castleman's disease was correlated with the responses to treatment, clinical and pathological subtypes. MCD and plasma cell subtype had worse prognosis. Conclusion LCD and MCD are two types of CD with distinct clinical manifestations and prognosis. Regarding the variation in pathogenesis and comorbidities, subtype differential diagnosis is of critical significance.
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