目的：观察氯氮平和喹硫平对慢性精神分裂症的治疗效果及治疗后患者认知功能的变化。方法选取2010-02-2012-11在我院就诊的90例慢性精神分裂症患者，将经典抗精神病药物随机分配替换为氯氮平和喹硫平，分别对入组时和8个月末的精神症状及认知功能进行评估，用不良反应症状量表评定治疗16周后的不良反应。结果88例临床稳定型慢性精神分裂症患者在经氯氮平或喹硫平治疗8个月后精神症状均明显好转，8个月后的认知功能也有显著改善，差异有统计学意义（P＜0.05）。换药16周后喹硫平组患者出现活动减少、嗜睡、便秘、流涎、头晕及体质量增加等不良反应的发生率明显少于氯氮平组，差异有统计学意义（P＜0.05）。结论氯氮平和喹硫平对慢性精神分裂症均有显著治疗作用，且二者在认知功能的改善及疗效方面无显著差异，但与氯氮平相比，喹硫平的不良反应较少，是一种相对安全有效的抗精神病药物。%Objective To observe the efficacy and effects of clozapine and quetiapine on chronic schizophrenia patients and their cognitive function changes.Methods 90 patients with chronic schizophrenia admitted to our hospital from February 2010 to November 2012 were selected,and after the classic antipsychotic treatment,as to the poor efficacy or patients could not tol-erate the adverse reactions.The classical antipsychotics were randomly assigned to clozapine and quetiapine,respectively,and at the end of 8 months,psychiatric symptoms and cognitive function were assessed,symptom rating scale with adverse reac-tions was used to evaluate side effects after treatment for 16 weekends.Results psychotic symptoms of 88 clinically stable pa-tients after clozapine or quetiapine treatment for 8 months were significantly improved,their cognitive function after 8 months’ treatment also had been significantly improved.Difference was statistically significant(P<0.05).After 16 weeks,the incidence of side effects of patients with quetiapine ,such as reduced activity,lethargy,constipation,salivation,dizziness,and weight gain,was significantly less than that of the clozapine group(P<0.05),statistically significant.Conclusion clozapine and que-tiapine in chronic schizophrenia show a significant therapeutic effect,the efficacy and the improvement of cognitive function of them have no significant differences,but compared with clozapine,quetiapine have less side effects,and it is a relatively safe and effective antipsychotics.
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