甲苯胺蓝(toluidine blue,TB)是一种噻嗪类阳离子染料,呈碱性,可与组织细胞中的酸性物质结合,是核酸染色的重要染色剂.由于TB与核酸特异性结合,优先保留在癌组织中,因而常用于口腔、眼科、上消化道等恶性肿瘤的诊断,在医学领域中有重要的研究价值.除此之外,TB作为一种安全有效的光敏剂,广泛用于光动力抗微生物和抗肿瘤治疗中.文章就TB在口腔医学中的应用及研究现状做一综述.%Toluidine blue (TB),an alkaline thiazide cationic dye,which can be combined with the acidic substances in the tissue cells,is an important dye for nucleic acid staining.Because of the specific binding of TB to nucleic acids,TB can be retained in cancer tissue preferentially and widely used in the diagnosis of malignant tumors of the mouth,the eye,and the upper digestive tract.TB plays an important role in medical research.In addition,as an effective photosensitizer,TB can be widely used in photodynamic antimicrobial and antitumor therapy.The purpose of this review is to provide a summary about the research situation and the application of TB in oral medicine.
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