Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine

YUAN Lin; LI Zhong-Yan; ZHANG Min; YUAN Xian-You

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Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine

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The title compound 2-(4-chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine(C_(19)H_(17)ClN_2) was synthesized and characterized by elemental analysis, ~1H NMR, HRMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to orthorhombic system,space group Pnma with a = 11.385(2), b = 12.170(2), c = 11.210(2) ?, V = 1553.2(5) ?~3, Z = 4, Dc =1.321 g/cm^3, m(Mo-Ka) = 0.244 mm^(-1), F(000) = 648, S = 1.309, R = 0.0400 and w R(I > 2s(I)) =0.1065. X-ray diffraction results showed that the molecular structure is highly symmetric and the new-formed N-heterocyclic ring is non-planar. In addition, the biological experiment showed that the title compound showed inhibitory activities against fungi with varied potencies.

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《结构化学》 |2016年第8期|1181-1185|共5页
作者
YUAN Lin; LI Zhong-Yan; ZHANG Min; YUAN Xian-You;
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Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China;

Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China;

Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China;

Department of Biology and Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China;

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Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine

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