Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno3,4-d1,2,3diazaphosphole

YING Hua-Zhou; SUN Mao-Tang; LIU Tao; HU Yong-Zhou

首页> 中文期刊> 《结构化学》 >Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno3,4-d1,2,3diazaphosphole

Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno3,4-d1,2,3diazaphosphole

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The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a=4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P=Mr=633.44) was synthesized and its structure was characterized by IR=MS=1H NMR=13C NMR=31P NMR=elemental analysis and single-crystal X-ray diffraction. It crystallizes in triclinic=space group P1=a=9.1549(3)=b=10.7168(4)=c=17.6272(6)=α=102.9363(12)=β=90.2713(9)=γ=117.4265(10)°=V=1484.41(9)3=Z=2=μ(MoKα)=0.323=F(000)=658=Z=2=Dc=1.417 g/cm3=the final R=0.0687 and wR=0.2066 for 4943 observed reflections (I >2σ(I)). X-ray analysis reveals that the diazaphospholine ring is almost planar and the two ethoxy groups bonded on the 3a- and 4-positions are in trans configurations. Its antiproliferative activity was also tested in vitro against four human tumor cell lines.

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来源
《结构化学》 |2008年第10期|1171-1174|共4页
作者
YING Hua-Zhou; SUN Mao-Tang; LIU Tao; HU Yong-Zhou;
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作者单位

ZJU-ENS Joint Laboratory of Medicinal Chemistry College of Pharmaceutical Science Zhejiang University Zijingang Campus Hangzhou 310058 China;

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正文语种 chi
中图分类结构化学;
关键词
synthesis; crystal structure; 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a; 4-diethoxy-2; 3; 3a; 4-tetrahydrochromeno3; 4-d1; 2; 3diazaphosphole; anti-tumor;

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Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno3,4-d1,2,3diazaphosphole

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