12-Phenyl-substituted-tetrahydro-β-carbolinediketopiperazine was synthesized from L-tryp-tophan methyl ester hydrochloride by a four-step reaction of Pictet-Spengler, Schotten-Baumann, intramolecular ester amidation and removing deprotection. The structures were characterized by 1H NMR, 13C NMR, IR and elemental analysis.%以L-色氨酸甲酯盐酸盐为原料,经Pictet-Spengler反应,Schotten-Baumann反应,酰胺键形成及脱保护4步反应合成了12-苯基取代四氢-β-咔啉二酮哌嗪,其结构经1 H NMR,13C NMR,IR和元素分析表征.
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