BACKGROUND:Compared with other calcium phosphate cemenst, brushite calcium phosphate cement has better biodegradabilityin vivo, as it can be quickly absorbed, which also causes a decrease of its mechanical characters. And it also suffers in application from its fast setting reaction and poor injectability. n OBJECTIVE:To cooperate β-tricalcium phosphate used as the main part of the solid phase with appropriate liquid phase to prepare a new brushite calcium phosphate cement formulation so as to improve the solidification properties and observe the controled drug-releasing capabilities. n METHODS:β-tricalcium phosphate was synthesized by calcining calcium carbonate and calcium hydrogen phosphate. The liquid phase was prepared by mixing citric acid, phosphorylated chitosan, gelation and hydroxypropyl methyl celulose in anaqueous solution. The solid phase which consisted of β-tricalcium phosphate and monocalcium phosphate was mixed with the liquid phase to acquire brushite calcium phosphate cement. Microstructure, composition, particle size and distribution, setting time, compressive strength and drug-releasing capability of the prepared brushite calcium phosphate cement were detected. n RESULTS AND CONCLUSION:β-tricalcium phosphate powder was a micro/nano blending system, with diameters of (2.24±0.38) μm in micron particle and (334.95±151.62) nm in nanoscale particle. Brushite belongs to lamelae tightly accumulated. The main component of the calcium phosphate cement powder was brushite, while a part of unreactedβ-tricalcium phosphate also existed. For the brushite calcium phosphate cement, the setting time was (6.20 ±1.30) minutes and the compressive strength was (22.90±3.13) MPa. The drug releasing experiment indicated that the brushite calcium phosphate cement also has certain controled-releasing capability.%背景：与其他磷酸钙类骨水泥相比，透钙磷石骨水泥在生物体内具有更好的生物降解能力，能被生物体较快吸收，但其在生物体内的机械性能会有所下降，同时其固化时间过快，可注射性较差。n 目的：以β-磷酸三钙为主体骨水泥粉末，搭配合适的骨水泥固化液，制备新型透钙磷石骨水泥，改善其固化性能，同时观察其载药性能。n 方法：以碳酸钙和磷酸氢钙为原料制备β-磷酸三钙粉末；将柠檬酸、磷酸化壳聚糖、明胶、羟丙基甲基纤维素与水混合溶解，制备骨水泥固化液，将β-磷酸三钙、一水合磷酸二氢钙的混合粉末与固化液混合制备透钙磷石骨水泥。考察透钙磷石骨水泥的微观形貌、组成成分、粒径大小及分布、固化时间、抗压强度及释药性能。n 结果与结论：β-磷酸三钙为微、纳米共混体系，微米级颗粒直径为(2.24±0.38)μm，纳米级颗粒直径为(334.95±151.62) nm；透钙磷石为片状结晶，堆积较为紧密。制备的骨水泥粉末主要成分为透钙磷石，同时还存有部分未反应的β-磷酸三钙。透钙磷石骨水泥的固化时间为(6.20±1.30) min，抗压强度为(22.90±3.13) MPa。药物释放实验证明透钙磷石骨水泥具有一定的缓释能力。
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