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Dicalcium phosphate cements: Brushite and monetite

机译：磷酸氢钙水泥：透钙磷石和透钙磷石

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摘要

Dicalcium phosphate cements were developed two decades ago and ever since there has been a substantial growth in research into improving their properties in order to satisfy the requirements needed for several clinical applications. The present paper presents an overview of the rapidly expanding research field of the two main dicalcium phosphate bioceramics: brushite and monetite. This review begins with a summary of all the different formulae developed to prepare dicalcium phosphate cements, and their setting reaction, in order to set the scene for the key cement physical and chemical properties, such as compressive and tensile strength, cohesion, injectability and shelf-life. We address the issue of brushite conversion into either monetite or apatite. Moreover, we discuss the in vivo behavior of the cements, including their ability to promote bone formation, biodegradation and potential clinical applications in drug delivery, orthopedics, craniofacial surgery, cancer therapy and biosensors.
机译：磷酸二钙水泥是二十年前开发的，从那时起，为了满足几种临床应用的要求，在改善其性能方面的研究已有了长足的发展。本文概述了两种主要的磷酸二钙生物陶瓷（透钙磷石和透钙磷石）的快速发展研究领域。这篇综述首先概述了制备磷酸二钙水泥所开发的所有不同配方及其凝结反应，以便为关键的水泥物理和化学特性（例如抗压强度和拉伸强度，内聚性，可注射性和货架性）奠定基础-生活。我们解决了将透钙磷石转化为褐铁矿或磷灰石的问题。此外，我们讨论了水泥的体内行为，包括其促进骨形成，生物降解的能力以及在药物输送，骨科，颅面外科手术，癌症治疗和生物传感器中的潜在临床应用。

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