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首页> 中文期刊> 《中国组织工程研究》 >GnRH及其受体的表达与胃腺癌细胞增殖和分化的相关性研究

GnRH及其受体的表达与胃腺癌细胞增殖和分化的相关性研究

         
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摘要

AIM:To investigate the possible correlation of the expression of gonadotropin releasing hormone(GnRH) and its receptor with of proliferating cell nuclear antigen(PCNA) in human gastric adenocarcinoma cell proliferation and differentiation.METHODS:GnRH and its receptor and PCNA were detected in 30 gastric adenocarcinoma by immunohistochemical ABC technique. RESULTS:GnRH and its receptor had the same distribution pattern in gastric adenocarcinoma cells.The positive signal was found mainly in cytoplasm.The content of GnRH and its receptor immunoreative product in high differentiatied adenocarcinoma was significantly higher than those of the other two groups and the low differentiatied adenocarcinoma was the lowest(P< 0.05).PCNA positive signal which was found mainly in nucleus was gradually abated along with the raising of the extent of the differentiation.The differences were significant among the three groups(P< 0.05). In human gastric adenocarcinoma,the expression of GnRH and its receptor was negative correlation with the expression of PCNA(r=0.9).CONCLUSION:GnRH might be involved in the regulation of human gastric adenocarcinoma cell proliferation and differentiation.

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  • 来源
    《中国组织工程研究》 |2003年第6期|1000-1001|共2页
  • 作者

    孙绪德; 柴伟; 高昌俊; 张贵和; 陈蕾; 黄威权;

  • 作者单位

    Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

    Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

    Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

    Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

    Department of Histology and Embryology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

    Department of Histology and Embryology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    stomach neoplasms; adenocarcinoma; gonadorelin; immunohistochemistry;

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