首页> 中文期刊> 《中国组织工程研究》 >肿瘤坏死因子-α和细胞粘附分子-1在脑缺血再灌注损伤中的表达规律

肿瘤坏死因子-α和细胞粘附分子-1在脑缺血再灌注损伤中的表达规律

         

摘要

Objective To detect the expression of TNF α and ICAM 1 in cerebral ischemia reperfusion injury. To explore their probable modulation mechanism.Methods Immunohistochemistry was used to examine the expression of TNF α and ICAM 1.The MPO activity was determined by spectrophotometry.Result The expression of TNF α and ICAM 1 were obviously rised after cerebral ischemia reperfusion (P< 0.05).Conclusion The up regulation of TNF α and ICAM 1 after cerebral ischemia reperfusion induced the accumulation of leukocytes, which involved in ischemia reperfusion injury mechanism. TNF α play an important role in expression of ICAM 1.

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