目的 探讨超声弹性组织弥散定量分析对酒精性肝纤维化的诊断价值及与肝纤维化程度的相关性.方法 选长期饮酒史患者85例,进行肝穿前行超声弹性组织弥散定量分析,选取定量参数:蓝色区域百分比.根据病理分期进行对比分析研究.结果 蓝色区域百分比在不同肝纤维化病理分期组间差异有统计学意义(P＜0.05).蓝色区域百分比与肝纤维化病理分期的相关系数r=0.87,P=0.000,两者存在显著正相关关系,随肝纤维化病理分期的升高,蓝色区域百分比随之升高.S0期95％的可信区间4.61％～8.32％.S1期95％的可信区间为12.35％～18.62％,S2期95％的可信区间为22.84％～29.37％.S3期95％的可信区间为32.64％～37.36％,S4期95％的可信区间为39.67％～46.37％.结论 超声弹性组织弥散定量分析能无创定量评价酒精性肝纤维化程度,有助于肝纤维化诊断及治疗评估.%Objective To investigate correlation of the dignostic performance of the ultrasonic elastic quantitative analysis of organization diffusion and the stage of alcoholic liver fibrosis.Methods 135 cases with chronic hepatitis B were examined with ultrasonic elastic quantitative analysis of organization diffusion before liver biopsy.It was taken to analysis the ROI area percentage of the blue color by the quantitative analysis of tissue diffusion.The elastogram were compared with the stage of liver fibrosis.Results The difference among the groups' elastogram ROI area percentage of the blue color was statistically significant.The correlation coefficient of the ROI area percentage of the blue color and pathological stage of liver fibrosis was r =0.86(P=0.000).Percentage of blue area increased with the stage of liver fibrosis increased.The CI of the quantitative analysis of organization diffusion scores,with the liver fibrosis patlmlooy stags S0,S1,S2,S3 and S4,were 4.61％～8.32％,12.35％ ～ 18.62％,22.84％～29.37％,32.64～37.36％,39.67 ％ ～46.37 ％,respectively.Conclusions The ultrasonic elastic quantitative analysis of organization diffusion Can reflect the degree of alcoholic liver fibrosis,contribute to the diagnosis and treatment of liver fibrosis assessment.
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